drugset / Trial / NCT06726421

Systemic Therapy Alone or With Stereotactic Body Radiotherapy for Oligometastatic Kidney Cancer (STROKER Study)

NCT06726421

Phase 3 Recruiting 252 enrolled Sun Yat-sen University
RandomizedParallel-groupSingle-blindTreatment

Summary

This phase III randomized controlled trial evaluates the efficacy of stereotactic body radiation therapy (SBRT) in oligometastatic renal cell carcinoma. The study aims to determine if the addition of SBRT to standard systemic therapy prolong survival compared to the standard systemic therapy alone. In addition, the study will explore the impact of this combined modality therapy on patients' toxicity and quality of life. The researchers will compare SBRT plus standard systemic therapy to standard systemic therapy alone, which is targeted agents and immunotherapy in this case, to determine if SBRT could prolong survival.

Timeline

Start
2024-09-18
Primary completion
2030-09-30
Completion
2033-09-30

Drugs

EvaluationDrugModalityDoseRoute
Background Axitinib Small molecule
Background Cabozantinib Small molecule
Background Lenvatinib Small molecule
Background Pazopanib Small molecule
Background Sunitinib Small molecule

Indications