Best Hypnotic Drug Choice for Rapid Sequence Induction in the Operating Room

Phase 3 Recruiting 1218 enrolled Nantes University Hospital

RandomizedParallel-groupOpen-labelTreatment

Summary

The best hypnotic choice to optimize the balance between good intubation condition quality and hemodynamic stability during RSI performed in the operating theatre remained to be investigated. Therefore, a randomized study evaluating the efficacy of propofol, ketamine, and a combination of both is appropriate. So, we designed the HyPnotiKs randomized controlled study to investigate the efficacy of these hypnotic drugs in patients undergoing RSI in the operating theatre. The primary endpoint will be the successful tracheal intubation at the first attempt without major arterial hypotension event.

Timeline

Start: 2025-04-14
Primary completion: 2027-04-14
Completion: 2027-04-30

Publications

Grillot N, Volteau C, Quillet P, Ambrosi X, Caillard A, David JS, Blet A, Bouzat P, Blanchet L, Bruneau N, Chebbi N, Saint-Genis Q, Figueiredo S, Guinot PG, Joosten A, Le Guen M, Labaste F, Lasocki S, Oudot M, Pommier M, Rousseleau D, Verdonk F, Tching-Sin M, Faurel-Paul E, Counille F, Cosse C, Flattres Duchaussoy D, Cinotti R, Roquilly A. Best hypnotic drug choice for rapid sequence induction in the operating room: study protocol for a 3-arm superiority open-labeled randomized controlled trial with blinded evaluation of the primary outcome (the HyPnotiKs study). Trials. 2026 Jan 16;27(1):127. doi: 10.1186/s13063-026-09452-6.

Drugs

Evaluation	Drug	Modality	Dose	Route
Subject	Ketamine	Small molecule	1 mg/kg	Intravenous
Subject	Ketamine	Small molecule	2 mg/kg	Intravenous
Subject	Propofol	Small molecule	1 mg/kg	Intravenous
Subject	Propofol	Small molecule	2 mg/kg	Intravenous

Indications

No indication recorded.