drugset / Trial / NCT06737016
Efficacy and Safety of Tamsulosin for Children with Posterior Urethral Valve.
RandomizedParallel-groupOpen-labelTreatment
Summary
To determine whether there is a role for Tamsulosin, A Selective Alpha-1 Adrenergic Blocker, as therapy in children with Posterior Urethral Valve post valve ablation , and whether there are side effects involved.
Timeline
- Start
- 2024-11-01
- Primary completion
- 2026-05
- Completion
- 2026-11
Publications
- Background Austin PF, Homsy YL, Masel JL, Cain MP, Casale AJ, Rink RC. alpha-Adrenergic blockade in children with neuropathic and nonneuropathic voiding dysfunction. J Urol. 1999 Sep;162(3 Pt 2):1064-7. doi: 10.1016/S0022-5347(01)68067-4.
- Background Abraham MK, Nasir AR, Sudarsanan B, Puzhankara R, Kedari PM, Unnithan GR, Damisetti KR, Narayanan T. Role of alpha adrenergic blocker in the management of posterior urethral valves. Pediatr Surg Int. 2009 Dec;25(12):1113-5. doi: 10.1007/s00383-009-2469-9. Epub 2009 Sep 1.
Drugs
| Evaluation | Drug | Modality | Dose | Route |
|---|---|---|---|---|
| Subject | Tamsulosin | Other / unclassified | 0.1 mg | Oral |
| Subject | Tamsulosin | Other / unclassified | 0.2 mg | Oral |
| Background | Oxybutynin | Small molecule | 0.2 mg/kg | Oral |
| Background | Trimethoprim/sulfamethoxazole | Unknown | 2 mg/kg | Oral |