drugset / Trial / NCT06738966

A Study of BL0175 Injection in Postmenopausal Female Adults With HR-positive, Locally Advanced or Metastatic Cancer

NCT06738966

Phase 1 Recruiting 9 enrolled Shanghai Best-Link Bioscience, LLC
Non-randomizedSequentialOpen-labelTreatment

Summary

The goal of this clinical trial is to learn if the investigational drug BL0175 works to treat adult postmenopausal women with hormone receptor (HR)-positive, human epidermal growth factor receptor (HER2)-negative locally advanced or metastatic breast cancer, ovarian cancer and endometrial cancer. It will also learn about the safety of BL0175. The main questions it aims to answer are: * Does the investigational drug BL0175 is safe for participants after dosed -multiple times? * Which is the highest safety dose of BL0175 after multiple dose? * What medical problems do participants have when using BL0175? * Does the investigational drug BL0175 works for participants after dosed -multiple times?

Timeline

Start
2025-03-10
Primary completion
2026-02-20
Completion
2027-12-26

Drugs

EvaluationDrugModalityDoseRoute
Subject BL0175 Other / unclassified 50 mg
Subject BL0175 Other / unclassified 100 mg
Subject BL0175 Other / unclassified 200 mg
Subject BL0175 Other / unclassified 400 mg
Subject BL0175 Other / unclassified 500 mg