Recombinant Human Brain Natriuretic Peptide for the Recovery Stage of Septic Shock

Summary

As infection control improves and circulation stabilizes, treatment de-escalation of septic shock begins, accompanied by fluid redistribution from interstitial spaces to the vasculature, increasing cardiac volume load. Synthetic recombinant human BNP (rh-BNP) plays a role in inducing vasodilation, particularly in the venous system, alleviating cardiac congestion, and enhancing natriuresis and diuresis. Thus the investigators designed a single-center, prospective physiological study to evaluate the efficacy of standard rh-BNP infusion in reducing venous return and enhancing fluid removal, with a secondary objective of assessing the maintenance of perfusion pressure and tissue perfusion.

Timeline

Start

2025-12

Primary completion

2026-06

Completion

2026-09

Publications

• Luo JC, Mou T, Li M, Feng WT, Yue RM, Pan C, Huang XB, Kattan E, Zhang Y, Pan LA. Recombinant human brain natriuretic peptide for the recovery stage of septic shock: an interventional study protocol. BMJ Open. 2026 May 24;16(5):e110628. doi: 10.1136/bmjopen-2025-110628.

Drugs

Indications