Reinforced Pancreaticojejunostomy With or Without glubran2

Summary

Pancreatic fistula is one of the most serious complication after pancreatoduodenectomy. To reduce pancreatic fistula, many authors recommend different techniques in pancreatojejunostomy. The purpose of this study is to determine which is the best method in preventing pancreatic fistula by enforce pancreaticojejunostomy with tissue glue .

Timeline

Start

2025-01-15

Primary completion

2026-04-15

Completion

2026-05-15

Outcome

Met primary endpoint

paper POPF (Grade B/C) occurred in 3 patients (6%) in the Glubran®2 group versus 11 patients (22%) in the Control group (p = 0.041; Fisher's exact test). PMID 42381068 ↗

Publications

• Saleh SK, Farahat MS, Mohamed TA, Hendy MM. Impact of reinforced pancreaticojejunostomy with or without tissue adhesive glue modified cyanoacrylate following pancreaticoduodenectomy: a randomized controlled clinical trial. World J Surg Oncol. 2026 Jun 30;24(1):268. doi: 10.1186/s12957-026-04476-3.

Drugs

Indications