Short-course Radiotherapy Followed by CAPOX and Ivonescimab for Locally Advanced Rectal Cancer

Phase 2 Not yet recruiting 40 enrolled The First Affiliated Hospital of Zhengzhou University

NaSingle-groupOpen-labelTreatment

Summary

This study is a single-arm, prospective, phase II clinical study to evaluate the efficacy and safety of preoperative short-course radiotherapy combined with ivonescimab and chemotherapy + total mesorectal excision(TME) surgery in patients with advanced rectal cancer.

Timeline

Start: 2025-01-20
Primary completion: 2027-12-20
Completion: 2031-12-20

Drugs

Evaluation	Drug	Modality	Dose	Route
Subject	Ivonescimab	Monoclonal antibody	20 mg/kg	Intravenous

Indications

No indication recorded.