drugset / Trial / NCT06761027

mFOLFIRINOX Plus Anlotinib and Sintilimab for Advanced Pancreatic Cancer

NCT06761027

Phase 1/2 Recruiting 29 enrolled Fujian Provincial Hospital
NaSingle-groupOpen-labelTreatment

Summary

This study is a prospective, single-arm, multicenter, phase Ib/II clinical trial that treats previously untreated patients with locally advanced or metastatic pancreatic cancer using mFOLFIRINOX in combination with anlotinib and sintilimab. The purpose of this trial is to evaluate the efficacy and safety of this treatment regimen and to preliminarily explore the correlation between biomarkers and treatment outcomes.

Timeline

Start
2024-12-23
Primary completion
2027-03
Completion
2027-05

Drugs

EvaluationDrugModalityDoseRoute
Subject Catequentinib Small molecule 8 mg Oral
Subject Catequentinib Small molecule 10 mg Oral
Subject Sintilimab Monoclonal antibody