Effect of Probiotic Supplement on Improvement of Depressive Symptoms in Patients With Substance-Induced Depressive Disorder

Summary

This study investigates the potential of probiotics as a therapeutic intervention for Substance-Induced Depressive Disorder (SIDD). The primary question the study aims to answer is: Can a four-week course of probiotics improve depressive symptoms and alter immune markers in patients diagnosed with SIDD, compared to a placebo? The study uses a double-blind, placebo-controlled, randomized clinical trial design with 40 participants to explore this question by measuring clinical outcomes using BDI and HAM-A and immunological markers.

Timeline

Start

2022-07-15

Primary completion

2023-04-12

Completion

2023-04-12

Publications

• Mosavat SH, Sahraian A, Kalani M, Namjoyan F, Ghasemi Y. Effect of probiotic supplement on improvement of depressive symptoms in patients with substance-induced depressive disorder: a randomized, double-blind, placebo-controlled clinical trial. BMC Psychiatry. 2026 Mar 13;26(1):334. doi: 10.1186/s12888-026-07903-7.

Drugs

Indications