drugset / Trial / NCT06792682

The Safety and Efficacy of Umbilical Cord Blood Mononuclear Cells in Patients With Secondary Poor Graft Function After Hematopoietic Stem Cell Transplantation

NCT06792682

NaSingle-groupOpen-labelTreatment

Summary

This study is conducted in a prospective, single-center clinical design and is divided into two stages: dose escalation and dose extension. Patients meeting the diagnostic criteria of secondary poor graft function are selected as the study objects. The safety data of umbilical cord blood mononuclear cells in the treatment of secondary poor graft function are obtained through dose escalation stage, and then one dose is selected for dose extension stage to explore the efficacy of umbilical cord blood mononuclear cells in treating secondary poor graft function.

Timeline

Start
2025-02-14
Primary completion
2027-12
Completion
2028-02

Drugs

EvaluationDrugModalityDoseRoute
Subject Umbilical cord blood mononuclear cells Cell therapy 2e+06 cells/kg Intravenous
Subject Umbilical cord blood mononuclear cells Cell therapy 3.5e+06 cells/kg Intravenous
Subject Umbilical cord blood mononuclear cells Cell therapy 5e+06 cells/kg Intravenous

Indications

No indication recorded.