The Effect of Colchicine on the Occurrence of Atrial Fibrillation After Cardiac Surgery

Summary

Development of a new comprehensive method for perioperative prevention of atrial fibrillation paroxysms in cardiac surgery patients at the hospital stage. It is planned to recruit 70 patients who will undergo pericardial fenestration during the operation using the original technique during coronary artery bypass grafting (Patent No. 2647626 C1 Russian Federation), and will be prescribed colchicine (the drug "Colchicum-dispert") in the perioperative period in order to prevent the development of paroxysms of atrial fibrillation in the postoperative period, and 70 cardiac surgery patients operated on using the standard technique (without performing the pericardial fenestration procedure intraoperatively), receiving non-steroidal anti-inflammatory drugs in the postoperative period.

Timeline

Start

2025-01-20

Primary completion

2025-07-20

Completion

2026-02-20

Publications

• Diakova ML, Kuznetsov MS, Vechersky YY, Kim EB, Zyryanov SV, Petlin KA, Kozlov BN. A Combined Approach to the Prevention of Postoperative Atrial Fibrillation in Cardiac Surgery. Biomedicines. 2025 Aug 17;13(8):1999. doi: 10.3390/biomedicines13081999.

Drugs

Indications