Topical Tartrazine for Improved Skin Structure Visualization in Dermatology

Summary

The goal of this clinical trial is to learn if the topical application of tartrazine, an FDA-approved food dye, can help improve the transparency of the skin in healthy volunteers. The main questions it aims to answer are: * Can topical tartrazine application allow for temporary skin transparency? * What dose of tartrazine is required to achieve reversible skin transparency? Participants will: * Be given a patch test with four different doses of tartrazine * Have these patch tests placed on the back, stomach, and forearm * Have photographs taken every 5 minutes to see if transparency is achieved * Be called 48 hours later to check for any side effects

Timeline

Start

2026-05-11

Primary completion

2026-12

Completion

2026-12

Outcome

Outcome not reported

Stopped: “The investigators are revisiting in vitro and in vivo studies to ensure the ability to replicate the results of the original paper before proceeding to the pilot clinical study.”

Publications

• Results Ntziachristos V. Going deeper than microscopy: the optical imaging frontier in biology. Nat Methods. 2010 Aug;7(8):603-14. doi: 10.1038/nmeth.1483. Epub 2010 Jul 30.
• Results Ou Z, Duh YS, Rommelfanger NJ, Keck CHC, Jiang S, Brinson K Jr, Zhao S, Schmidt EL, Wu X, Yang F, Cai B, Cui H, Qi W, Wu S, Tantry A, Roth R, Ding J, Chen X, Kaltschmidt JA, Brongersma ML, Hong G. Achieving optical transparency in live animals with absorbing molecules. Science. 2024 Sep 6;385(6713):eadm6869. doi: 10.1126/science.adm6869. Epub 2024 Sep 6.

Drugs

Indications

No indication recorded.