drugset / Trial / NCT06802081

TIRzepatide for the Treatment of Obesity in Patients With Atrial Fibrillation

NCT06802081

Phase 2 Recruiting 100 enrolled The Cleveland Clinic
RandomizedParallel-groupTriple-blindTreatment

Summary

This is a single center randomized double blind controlled study of patients (BMI ≥ 27 kg/m2) with obesity and Atrial Fibrillation (AFIB) randomized to Tirzepatide vs. placebo. It is expected that the significant weight loss with Tirzepatide will result in improved control, management, symptom severity, and burden of AFIB at 12 months.

Timeline

Start
2025-04-08
Primary completion
2026-12-31
Completion
2027-06-01

Drugs

EvaluationDrugModalityDoseRoute
Subject Tirzepatide Peptide 10 mg Subcutaneous