Digital Intervention for Psychedelic Preparation (DIPP): Comparing Meditation and Music-Based Programs

Summary

This randomised controlled feasibility trial evaluates the Digital Intervention for Psychedelic Preparation (DIPP), a novel 21-day self-guided program designed to prepare individuals for psychedelic experiences. Forty healthy volunteers will be randomly assigned to either a meditation-based intervention or a music-based control condition. Both groups will follow identical program structures, with the key distinction being their daily practice focus: meditation or music listening. Following the 21-day preparation period, participants will undergo a supervised 25 mg psilocybin session at University College London. Assessment visits include an in-person follow-up at 2 weeks post-session, followed by online assessments at 3, 6, and 9 months. The primary outcomes include operational feasibility (recruitment rates and participant retention) and intervention adherence (completion rates of DIPP program activities). Secondary outcomes include participant ratings of the platform's feasibility, acceptability, and usability, as well as changes in psychedelic preparedness, the quality of the psychedelic experience, and mental wellbeing over time.

Timeline

Start

2025-03-01

Primary completion

2026-03

Completion

2026-12

Publications

• McAlpine R, Jaglinska M, Jedlovszky K, Kuc J, Castro A, Piot A, Timmermann C, Skipper JI, Sacchet MD, Kamboj SK. Digital Intervention for Psychedelic Preparation (DIPP): protocol for a randomised controlled feasibility trial comparing meditation- and music-based programmes in healthy volunteers. BMJ Open. 2026 Mar 12;16(3):e107512. doi: 10.1136/bmjopen-2025-107512.

Drugs

Indications

No indication recorded.