drugset / Trial / NCT06816524
The Effects of Iron Treatment on Malaria and Measles Vaccine Response in Kenyan Infants With Iron Deficiency
Not yet recruiting
324 enrolled
Nicole Stoffel
Faculty of Medical Sciences, Radboud University of Medical Center · collabJomo Kenyatta University of Agriculture and Technology · collabNational Institute for Public Health and the Environment (RIVM) · collabUniversity of Oxford - Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences · collab
RandomizedParallel-groupQuadruple-blindOther
Summary
Malaria and iron deficiency cause a significant burden of disease in Africa. Iron deficiency (ID) might affect immune responses to vaccination. In this double-blind randomized controlled trial, we aim to assess: (1) whether ID impairs R21/Matrix-M and measles (MR) vaccine response, (2) whether iron treatment at time of vaccination improves vaccine response.
Timeline
- Start
- 2026-01-05
- Primary completion
- 2027-12-31
- Completion
- 2028-04-30
Drugs
| Evaluation | Drug | Modality | Dose | Route |
|---|---|---|---|---|
| Subject | Measles-Rubella vaccine | Vaccine | — | — |
| Subject | R21-Matrix/M Vaccine (malaria vaccine) | Vaccine | — | — |