drugset / Trial / NCT06820255
DDR Genes Alteration and Response to Platinum-based Chemotherapy in Advanced Urothelial Cancer.
Non-randomizedParallel-groupTriple-blindDiagnostic
Summary
This study aims to prospectively observe whether certain alterations in some genes related to the DNA repair mechanism are related to better response to platinum-based chemotherapy used to treat metastatic bladder or urothelial cancers.
Timeline
- Start
- 2025-01-07
- Primary completion
- 2026-01-07
- Completion
- 2027-01-07
Drugs
| Evaluation | Drug | Modality | Dose | Route |
|---|---|---|---|---|
| Comparator | Avelumab | Monoclonal antibody | 800 mg | — |
| Comparator | Carboplatin | Small molecule | — | — |
| Comparator | Cisplatin | Other / unclassified | — | — |
| Comparator | Gemcitabine | Small molecule | — | — |