drugset / Trial / NCT06822166
Drug Interactions Trial of Methoxyethyl Etomidate Hydrochloride
Non-randomizedCrossoverOpen-labelOther
Summary
Sixty-eight healthy subjects were divided into three sequences: A, B and C. The effects of CYP2C19 inhibitor fluconazole and inducer rifampicin on ET-26-HCl injection were evaluated, and the effects of ET-26-HCl injection on pharmacokinetics of omeprazole and midazolam were evaluated.
Timeline
- Start
- 2023-12-04
- Primary completion
- 2024-01-23
- Completion
- 2024-01-23
Drugs
| Evaluation | Drug | Modality | Dose | Route |
|---|---|---|---|---|
| Subject | ET-26 | Unknown | 0.8 mg/kg | — |
| Subject | Fluconazole | Small molecule | 200 mg | — |
| Subject | Midazolam | Small molecule | 0.05 mg/kg | Intravenous |
| Subject | Omeprazole | Other / unclassified | 20 mg | — |
| Subject | Rifampin | Small molecule | 600 mg | — |
Indications
No indication recorded.