Allergenic Extract Standardized Cat Hair AP in an Allergic Rhinitis Model.

Summary

The goal of this study is to learn if a cat allergen extract known as Allergenic Extract Standardized Cat Hair Acetone Precipitated (AP Cat) can induce allergic rhinitis (AR) in a nasal allergen challenge model in cat-allergic people. The main questions this study aims to answer are: 1. Does AP Cat induce nasal symptoms of allergic rhinitis in cat-allergic participants when delivered intranasally? 2. Does AP Cat reduce elements in the blood and nose that are known to be associated with allergies? Both allergic and non-allergic participants will be recruited into this study. Allergic participants will: * Be challenged with AP Cat via the Nasal Allergen Challenge (NAC), which involves administration of this allergen extract directly into the nose. * Have nasal fluid and blood samples collected at various timepoints up to 24 hours after exposure to the allergen in the NAC. * Visit the study site three separate times: 1. At screening (Visit 1), to determine eligibility to participate in this study 2. At the baseline NAC visit (Visit 2) 3. At the 24-hour post-NAC follow-up visit (Visit 3) * Complete nasal symptom questionnaires. * Complete a questionnaire about their regular exposure to cats. Non-allergic participants will: * Be challenged with AP Cat via the NAC, which involves administration of this allergen extract directly into the nose. * Have nasal fluid and blood samples collected at various timepoints up to 24 hours after exposure to the allergen in the NAC. * Visit the study site three separate times: 1. At screening (Visit 1), to determine eligibility to participate in this study 2. At the baseline NAC visit (Visit 2) 3. At the 24-hour post-NAC follow-up visit (Visit 3) * Complete nasal symptom questionnaires. This study will compare the nasal symptoms and allergic markers collected from the nasal fluid and blood samples between allergic and non-allergic participants at baseline and various timepoints post-NAC exposure.

Timeline

Start

2025-03-04

Primary completion

2026-01-08

Completion

2026-06

Drugs

Indications