drugset / Trial / NCT06835530

A Combination of Rituximab and CC-99282 as Front-line Therapy for Older Frail Patients With Diffuse Large B-cells Non-Hodgkin Lymphoma Evaluated With a Simplified Geriatric Assessment (sGA): a Phase II Study of the Fondazione Italiana Linfomi (FIL)

NCT06835530

Phase 2 Recruiting 47 enrolled Fondazione Italiana Linfomi - ETS
NaSingle-groupOpen-labelTreatment

Summary

Prospective, multicenter, single arm, phase II study, to evaluate the efficacy of the combination rituximab-golcadomide as a chemo free approach in a population of older patients with new diagnosis of DLBCL, defined as frail according to a sGA evaluation and not candidate for the standard R-CHOP (or R-CHOP like) treatments.

Timeline

Start
2025-04-09
Primary completion
2030-04
Completion
2030-04

Drugs

EvaluationDrugModalityDoseRoute
Subject Golcadomide Other / unclassified 0.4 mg Oral
Subject Rituximab Monoclonal antibody 375 mg/m2 Intravenous