Psilocybin Brain Stimulation and Imaging Pilot Study

Phase 1 Active not recruiting 15 enrolled Johns Hopkins University

NaSingle-groupOpen-labelBasic science

Summary

This open-label pilot psilocybin administration study investigates the influence of psilocybin on brain function and cognitive control functions in clinically and psychiatrically healthy volunteers. Participants will undergo experimental drug administration sessions after careful screening and preparation. Participants will also have brain activity measured using electroencephalogram (EEG) also during non-invasive brain stimulation using Transcranial Magnetic Stimulation (TMS).

Timeline

Start: 2025-04-18
Primary completion: 2026-08
Completion: 2026-08

Publications

Atiq MA, Weisman E, Guerra RB, Martinez LL, Yaden DB, Barrett FS, Nayak S, Sayali C. Psilocybin-induced neurocardiogenic syncope: a case report. Psychopharmacology (Berl). 2026 May 28. doi: 10.1007/s00213-026-07079-8. Online ahead of print.

Drugs

Evaluation	Drug	Modality	Dose	Route
Subject	Psilocybin	Other / unclassified	25 mg	Oral

Indications

No indication recorded.