drugset / Trial / NCT06839391
Effect of Hyaluronidase in Different Doses Added to Bupivacaine on TAB Block Quality During CS
RandomizedParallel-groupOpen-labelHealth-services research
Summary
evaluate the efficacy of hyaluronidase in different doses as an adjuvant to bupivacaine in ultrasound-guided TAB block during CS
Timeline
- Start
- 2025-03
- Primary completion
- 2026-03
- Completion
- 2026-04
Publications
- Background Keeler JF, Simpson KH, Ellis FR, Kay SP. Effect of addition of hyaluronidase to bupivacaine during axillary brachial plexus block. Br J Anaesth. 1992 Jan;68(1):68-71. doi: 10.1093/bja/68.1.68.
- Background Koh WU, Min HG, Park HS, Karm MH, Lee KK, Yang HS, Ro YJ. Use of hyaluronidase as an adjuvant to ropivacaine to reduce axillary brachial plexus block onset time: a prospective, randomised controlled study. Anaesthesia. 2015 Mar;70(3):282-9. doi: 10.1111/anae.12879. Epub 2014 Oct 28.
- Background Kumar CM, Macachor J. Hyaluronidase for brachial plexus block. Anaesthesia. 2015 Sep;70(9):1097-8. doi: 10.1111/anae.13186. No abstract available.
Drugs
| Evaluation | Drug | Modality | Dose | Route |
|---|---|---|---|---|
| Subject | rHuPH20 | Protein / enzyme biologic | 500 iu | — |
| Subject | rHuPH20 | Protein / enzyme biologic | 1000 iu | — |
Indications
No indication recorded.