Trop2-targeted immunoPET Imaging of Solid Tumors

Summary

This study aims to establish and optimize the trophoblast cell surface antigen 2 (Trop2)-targeted immuno-positron emission tomography/computed tomography (immunoPET/CT) imaging method and its physiological and pathological distribution characteristics, based on which the diagnostic efficacy of the above imaging agents in solid tumors (including uroepithelial cancer, bladder cancer, prostate cancer, lung cancer, nasopharyngeal cancer, liver cancer, cholangiocarcinoma, ovarian cancer, cervical cancer, endometrial cancer, thyroid cancer, head and neck cancer) will be evaluated.

Timeline

Start

2024-12-23

Primary completion

2027-12

Completion

2027-12

Publications

• Long X, An S, Nian X, Xu D, Wei W, Lan X, Dong L, Jiang D. Trop2 immuno-PET/CT imaging of prostate cancer: a proof-of-concept translational study. BMC Med. 2025 Dec 31;24(1):66. doi: 10.1186/s12916-025-04589-8.

Drugs

Indications