drugset / Trial / NCT06870448

Methylprednisolone With Endovascular Thrombectomy for Large Ischemic Stroke

NCT06870448

Phase 3 Not yet recruiting 1614 enrolled Sun Yat-Sen Memorial Hospital of Sun Yat-Sen University
RandomizedParallel-groupQuadruple-blindTreatment

Summary

It is uncertain whether intravenous methylprednisolone improves outcomes for acute anterior circulation large vascular occlusion (LVO) patients with a large infarct core. In this study, the investigators assume that methylprednisolone plus endovascular thrombectomy (EVT) might be superior to EVT alone for patients who have evidence of a large infarct volume. The objective of the study was to establish the efficacy and safety of methylprednisolone with EVT in patients presenting with symptoms of acute ischemic stroke from LVO in the anterior circulation and having a large infarct volume.

Timeline

Start
2025-04
Primary completion
2029-01
Completion
2029-04

Drugs

EvaluationDrugModalityDoseRoute
Subject Methylprednisolone Other / unclassified 2 mg/kg Intravenous

Indications