drugset
drugset / Trial / NCT06878742

Dose-finding for Dobutamine During Transitional Circulation in Very Preterm Infants

NCT06878742 ↗

Phase 1/2 Recruiting 30 enrolled Instituto de Investigación Hospital Universitario La Paz
Non-randomizedParallel-groupOpen-labelTreatment

Summary

Single centre, dose finding trial to establish the minimum effective dose of dobutamine required to treat hemodynamic insufficiency, defined as low superior vena cava (SVC) flow, in infants below 33 weeks' gestation during transitional circulation (first 72 hours from birth).

Timeline

Start
2024-06-24
Primary completion
2029-06
Completion
2029-06

Drugs

EvaluationDrugModalityDoseRoute
Subject Dobutamine Small molecule 5 ug/kg Intravenous
Subject Dobutamine Small molecule 7.5 ug/kg Intravenous
Subject Dobutamine Small molecule 10 ug/kg Intravenous
Subject Dobutamine Small molecule 12.5 ug/kg Intravenous
Subject Dobutamine Small molecule 15 ug/kg Intravenous

Indications

No indication recorded.