drugset / Trial / NCT06880601

Teclistamab Plus Autologous Lymphocyte Infusion (ALI) for the Treatment of R/R Multiple Myeloma

NCT06880601

Phase 2 Not yet recruiting 52 enrolled GIMEMA Foundation
NaSingle-groupOpen-labelTreatment

Summary

The goal of this clinical trial is to evaluate the efficacy of Teclistamab (Te) and autologous lymphocyte infusions (ALI) in relapse refractory multiple myeloma. The main question it aims to answer is: which is the Duration of response (DoR) with Teclistmab and ALI? Participants will receive Te for 5 cycles. Participants in PR or better after the first five cycles of Te monotherapy will continue treatment with Te in combination with ALI administration starting from cycle 6

Timeline

Start
2025-11-01
Primary completion
2029-11-01
Completion
2029-11-01

Drugs

EvaluationDrugModalityDoseRoute
Subject Teclistamab Monoclonal antibody 3 mg/kg Subcutaneous

Indications