Prevention of Nephrotoxin-Induced Acute Kidney Injury Using Cilastatin

Summary

The goal of this clinical trial is to repurpose cilastatin for preventing acute kidney injury (AKI) in hospitalized patients receiving nephrotoxic medications. The trial will evaluate the efficacy of the re-purposed drug. The main questions it aims to answer are: \- whether cilastatin will prevent nephrotoxic AKI in hospitalized patients. Researchers will compare the drug cilastatin to a placebo (a look-alike substance that contains no drug) to see if drug cilastatin works to prevent AKI in hospitalized patients receiving nephrotoxic medications. Participants will: * Receive drug Cilastatin or a placebo intravenously every 6 hours for up to 24 hours after last exposure to nephrotoxic medication * Have blood test for kidney function every day they are on treatment. * Have a follow-up blood test at 90 days after randomization * Have a telephone survey at 90 days after randomization

Timeline

Start

2025-07-16

Primary completion

2027-12-31

Completion

2029-12

Publications

• Background Elliott MJ, Fiest KM, Love S, Birdsell D, Loth M, Dumka H, Rana B, Shommu N, Benterud E, Gil S, Acharya D, Harrison TG, Pannu N, James MT. Patient Preferences and Priorities for the Design of an Acute Kidney Injury Prevention Trial: Findings from a Consensus Workshop. Kidney360. 2024 Oct 1;5(10):1455-1465. doi: 10.34067/KID.0000000000000554. Epub 2024 Aug 15.
• Background Acharya D, Ghanim F, Harrison TG, Scory TD, Shommu N, Ronksley PE, Elliott MJ, Collister D, Pannu N, James MT. Nephroprotective Effects of Cilastatin in People at Risk of Acute Kidney Injury: A Systematic Review and Meta-analysis. Kidney Med. 2024 Oct 11;6(12):100913. doi: 10.1016/j.xkme.2024.100913. eCollection 2024 Dec.

Drugs

Indications