Propolis Lozenges Extract and Their Effect on Salivary Biomarkers and on Oral Health Condition in (19_24) Years Old

Summary

The goal of this clinical trial is to test the efficiency of using lozenges containing propolis extract over one week to control gingival inflammation and plaque accumulation by measuring the clinical periodontal parameters (Gingival index, plaque index) in comparison with a control group given oral hygiene instruction only in patients with biofilm induced gingivitis (moderate gingivitis) Objectives: 1. Evaluate the clinical efficiency of using lozenges containing propolis extract over 7 days to control gingival inflammation and plaque accumulation by measuring the clinical periodontal parameters (Gingival index, plaque index) in comparison with a control group given oral hygiene instruction only in patients with biofilm induced gingivitis (moderate gingivitis). 2. Measuring levels of salivary cytokines, IL-1Beta, and IL-10 by ELISA at Baseline visit before using lozenges containing propolis and after 7 days of using lozenges containing propolis compared to a control group with oral hygiene instruction only. 3. Investigate and compare the association of salivary interleukins of IL-Beta and IL-10 in periodontal health and generalized gingivitis. 4. Evaluate the correlation between clinical periodontal parameters and salivary (IL-1Beta and IL-10). 5. Evaluate subjects' perception of lozenges containing propolis extract and oral hygiene instructions after 7 days.

Timeline

Start

2025-03-23

Primary completion

2025-04-01

Completion

2025-04-20

Publications

• Background Shi H, Yang H, Zhang X, Yu LL. Identification and quantification of phytochemical composition and anti-inflammatory and radical scavenging properties of methanolic extracts of Chinese propolis. J Agric Food Chem. 2012 Dec 19;60(50):12403-10. doi: 10.1021/jf3042775. Epub 2012 Dec 5.
• Background El-Allaky HS, Wahba NA, Talaat DM, Zakaria AS. Antimicrobial Effect of Propolis Administered through Two Different Vehicles in High Caries Risk Children: A Randomized Clinical Trial. J Clin Pediatr Dent. 2020 Sep 1;44(5):289-295. doi: 10.17796/1053-4625-44.5.1.
• Background Alghutaimel H, Matoug-Elwerfelli M, Alhaji M, Albawardi F, Nagendrababu V, Dummer PMH. Propolis Use in Dentistry: A Narrative Review of Its Preventive and Therapeutic Applications. Int Dent J. 2024 Jun;74(3):365-386. doi: 10.1016/j.identj.2024.01.018. Epub 2024 Feb 19.

Drugs

Indications