drugset / Trial / NCT06898788
Probiotic Administration for Adolescent Depression
Phase 0
Recruiting
77 enrolled
University of California, San Francisco
National Center for Complementary and Integrative Health (NCCIH) · collab
RandomizedParallel-groupTriple-blindOther
Summary
This double-blind, placebo-controlled clinical trial will examine the effect of probiotic Visbiome on the brain and gut microbiome of individuals 15 to 24 years of age.
Timeline
- Start
- 2025-05-15
- Primary completion
- 2026-08
- Completion
- 2026-12
Publications
- Background Ouwehand AC, Invernici MM, Furlaneto FAC, Messora MR. Effectiveness of Multistrain Versus Single-strain Probiotics: Current Status and Recommendations for the Future. J Clin Gastroenterol. 2018 Nov/Dec;52 Suppl 1, Proceedings from the 9th Probiotics, Prebiotics and New Foods, Nutraceuticals and Botanicals for Nutrition & Human and Microbiota Health Meeting, held in Rome, Italy from September 10 to 12, 2017:S35-S40. doi: 10.1097/MCG.0000000000001052.
- Background Liu RT, Walsh RFL, Sheehan AE. Prebiotics and probiotics for depression and anxiety: A systematic review and meta-analysis of controlled clinical trials. Neurosci Biobehav Rev. 2019 Jul;102:13-23. doi: 10.1016/j.neubiorev.2019.03.023. Epub 2019 Apr 17.
Drugs
| Evaluation | Drug | Modality | Dose | Route |
|---|---|---|---|---|
| Comparator | Visbiome | Other / unclassified | 4.5e+11 cells | Oral |