Direct Comparison of Altered States of Consciousness Induced by LSD, Psilocybin, and DMT in Healthy Participants

Phase 1 Recruiting 24 enrolled University Hospital, Basel, Switzerland

RandomizedCrossoverTriple-blindBasic science

Summary

The primary objective of this study is to determine whether equivalent moderately high doses of LSD, psilocybin, and DMT produce qualitatively similar peak effects when the effect duration is standardized with ketanserin. A DMT infusion mimicking oral LSD and psilocybin administrations will be tested, as well as intravenously administered ketanserin.

Timeline

Start: 2025-04-01
Primary completion: 2026-08-01
Completion: 2026-08-01

Drugs

Evaluation	Drug	Modality	Dose	Route
Subject	Lysergic Acid Diethylamide	Other / unclassified	150 ug	Oral
Subject	N,N-dimethyltryptamine	Unknown	2 mg	Intravenous
Subject	Psilocybin	Other / unclassified	30 mg	Oral
Background	Ketanserin	Small molecule	20 mg	Intravenous

Indications

No indication recorded.