drugset / Trial / NCT06957834

Efficacy of Eflornithine Hydrochloride Cream in the Treatment of Melasma: A Randomized, Double-blinded, Split-face Controlled Study

NCT06957834

Phase 2 Completed 20 enrolled National Skin Centre
RandomizedCrossoverQuadruple-blindTreatment

Summary

The goal of this clinical trial is to learn if Eflornithine hydrochloride cream works to treat melasma in adults, in comparison to Hydroquinone cream. It will also learn about the safety of Eflornithine hydrochloride cream. The main questions it aims to answer are: * Does Eflornithine hydrochloride improve melasma assessment scores over a 3-month duration compared to Hydroquinone cream? * What side effects might patients get while using Eflornithine hydrochloride cream? Participants will: * Apply both Eflornithine hydrochloride and Hydroquinone creams on separate halves of their faces every day for 3 months. * Visit the clinic once at the 2-month mark and once at the 3-month mark for checkups and tests.

Timeline

Start
2023-06-06
Primary completion
2024-07-11
Completion
2024-07-11

Drugs

EvaluationDrugModalityDoseRoute
Comparator Eflornithine Small molecule 11.5 % Topical
Comparator Hydroquinone Small molecule 2 % Topical