Linezolid Plus Standard of Care

Summary

The aim of the study is to assess whether targeting virulence factors by administering linezolid in addition to standard antibiotic treatment improves outcomes in patients with Staphylococcus aureus bacteraemia.

Timeline

Start

2025-10-06

Primary completion

2028-10

Completion

2028-10

Publications

• Rose N, Bernasconi NS, Schumacher M, Werlen L, Buchel D, Weisser M, Vogt SB, Wehrle-Wieland E, Conen A, Thurnheer MC, Martin Y, Birrer M, Bongiovanni M, Albrich WC, Karrer U, Schibli A, Harbarth S, Papadimitriou-Olivgeris M, Briel M, Hasse B, Khanna N, Kuehl R, Speich B. Linezolid in addition to standard antibiotic treatment for Staphylococcus aureus bacteraemia: study protocol for a randomised, placebo-controlled trial. BMJ Open. 2026 Apr 20;16(4):e118509. doi: 10.1136/bmjopen-2026-118509.

Drugs

Indications