drugset / Trial / NCT06961370

A Study to Investigate Safety, Tolerability, Pharmacokinetics (PK), Pharmacodynamics (PD), and Immunogenicity of RO7669330 in Participants With Geographic Atrophy (GA) Secondary to Age-related Macular Degeneration (AMD)

NCT06961370

Phase 1 Active not recruiting 27 enrolled Hoffmann-La Roche
RandomizedParallel-groupTriple-blindTreatment

Summary

The main purpose of this study is to assess the ocular and systemic safety and tolerability of RO7669330 in participants with GA secondary to AMD in at least one eye in Part 1, or both eyes in Part 2, after multiple unilateral intravitreal (IVT) doses.

Timeline

Start
2025-07-16
Primary completion
2027-01-03
Completion
2027-01-03

Drugs

EvaluationDrugModalityDoseRoute
Subject Avacincaptad Pegol Aptamer 2 mg Intravitreal
Subject Pegcetacoplan Peptide 15 mg Intravitreal
Subject RO7669330 Unknown Intravitreal