A Clinical Study on the Efficacy and Safety of Zonisamide as a First Add-On Treatment in Epileptic Seizures

Phase 4 Recruiting 30 enrolled Affiliated Hospital of Nantong University

NaSingle-groupOpen-labelTreatment

Summary

This study primarily aims to assess the efficacy and safety of zonisamide when used as an adjunctive therapy for focal epilepsy. The main questions it aims to answer are: 1. Does the frequency of epileptic seizures decrease after oral zonisamide， and does it improve cognitive function? 2. Are there any treatment-emergent adverse events associated with oral administration of zonisamide?

Timeline

Start: 2024-08-01
Primary completion: 2027-07-31
Completion: 2027-07-31

Publications

Background Cho D, Yu MS, Shin J, Lee J, Kim Y, Kang HC, Kim SH, Na D. A computational clinical decision-supporting system to suggest effective anti-epileptic drugs for pediatric epilepsy patients based on deep learning models using patient's medical history. BMC Med Inform Decis Mak. 2024 May 31;24(1):149. doi: 10.1186/s12911-024-02552-w.

Drugs

Evaluation	Drug	Modality	Dose	Route
Subject	Zonisamide	Other / unclassified	4 mg/kg	Oral
Subject	Zonisamide	Other / unclassified	6 mg/kg	Oral

A Clinical Study on the Efficacy and Safety of Zonisamide as a First Add-On Treatment in Epileptic Seizures

Summary

Timeline

Publications

Drugs

Indications