A Study to Investigate if Long Acting Cabotegravir (CAB) and Lenacapavir (LEN) Injections Are Tolerable and Acceptable When Administered to Healthy Adults Without HIV

Phase 1 Active not recruiting 65 enrolled ViiV Healthcare

RandomizedCrossoverOpen-labelPrevention

Summary

This study will evaluate the tolerability and acceptability of injection site reactions (ISRs) of two long-acting (LA) injectables. Additional characteristics of the ISRs will be investigated and described as well as safety outcomes.

Timeline

Start: 2025-04-22
Primary completion: 2025-07-15
Completion: 2026-07-10

Drugs

Evaluation	Drug	Modality	Dose	Route
Subject	Cabotegravir	Small molecule	—	Intramuscular
Subject	Lenacapavir	Small molecule	—	Subcutaneous

A Study to Investigate if Long Acting Cabotegravir (CAB) and Lenacapavir (LEN) Injections Are Tolerable and Acceptable When Administered to Healthy Adults Without HIV

Summary

Timeline

Drugs

Indications