drugset / Trial / NCT06973291

A Study Comparing Zasocitinib (TAK-279) With Deucravacitinib in Adults With Plaque Psoriasis

NCT06973291

Phase 3 Completed 606 enrolled Takeda
RandomizedParallel-groupDouble-blindTreatment

Summary

The main aim of this study is to assess whether zasocitinib works better than deucravacitinib in treating participants with moderate-to-severe plaque psoriasis. Participants will take one tablet daily of either zasocitinib or a matching placebo, along with one capsule daily of either over-encapsulated deucravacitinib or a matching placebo, for a duration of 16 weeks. Participants will be in the study for up to 25 weeks, which includes screening period of up to 35 days, a 16-week treatment period, and a 4-week safety follow-up period.

Timeline

Start
2025-07-09
Primary completion
2026-04-22
Completion
2026-04-22

Drugs

EvaluationDrugModalityDoseRoute
Comparator CRAVACITINIB Small molecule 6 mg Oral
Subject Zasocitinib Small molecule Oral

Indications