drugset / Trial / NCT07011693
Switching Medication and Augmentation Strategies for SSRI-Resistant Adolescent Depression（SMART-I)
RandomizedParallel-groupSingle-blindTreatment
Summary
This project aims to investigate the effectiveness of existing common antidepressants in adolescents with MDD who did not respond to their first treatment.
Timeline
- Start
- 2025-06-20
- Primary completion
- 2027-06
- Completion
- 2027-12
Drugs
| Evaluation | Drug | Modality | Dose | Route |
|---|---|---|---|---|
| Subject | Agomelatine | Small molecule | 25 mg | Oral |
| Subject | Agomelatine | Small molecule | 50 mg | Oral |
| Subject | Aripiprazole | Other / unclassified | 1.25 mg | Oral |
| Subject | Aripiprazole | Other / unclassified | 15 mg | Oral |
| Subject | Sertraline | Small molecule | 25 mg | Oral |
| Subject | Sertraline | Small molecule | 200 mg | Oral |