drugset / Trial / NCT07044297

A Clinical Study of MK-8527 to Prevent Human Immunodeficiency Virus Type 1 (HIV-1) (MK-8527-011)

NCT07044297

Phase 3 Recruiting 4390 enrolled Merck Sharp & Dohme LLC
RandomizedParallel-groupDouble-blindTreatment

Summary

Researchers are looking for new medicines to prevent HIV-1 (Human Immunodeficiency Virus Type 1) infection. The goals of this study are to learn: * If taking MK-8527 once a month works to prevent HIV-1 infection as well as or better than a standard (usual) pre-exposure prophylaxis (PrEP) taken once a day * About the safety of MK-8527 and if people tolerate it

Timeline

Start
2025-07-31
Primary completion
2027-07-22
Completion
2027-07-22

Drugs

EvaluationDrugModalityDoseRoute
Subject FTC Unknown 200 mg Oral
Subject MK-8527 Small molecule 11 mg Oral
Subject TDF Unknown 245 mg Oral