Ketamine and Levetiracetam as Second-line Antiseizure Medication for Status Epilepticus in Children

Summary

About 40% of children with generalized convulsive status epilepticus (GCSE) are not terminated by first-line benzodiazepines (BDZs), and approximately 50% of BDZ-refractory GCSE are not controlled by second-line antiseizure medications. This study investigates the efficacy of ketamine-levetiracetam combination vs. levetiracetam alone for treating children with BDZ-refractory GCSE.

Timeline

Start

2025-07-02

Primary completion

2026-06-30

Completion

2026-07-01

Drugs

Indications