Rituximab and Targeted Nursing for Pediatric Nephrotic Syndrome

Summary

This study investigated the combined impact of rituximab and targeted nursing care versus tacrolimus and targeted nursing care on efficacy, quality of life, adverse reactions, and recurrence rate in children with challenging (steroid-dependent or frequently relapsing) nephrotic syndrome. Ninety-one pediatric patients were randomized to either receive rituximab plus targeted nursing or tacrolimus plus targeted nursing, and outcomes were assessed over a 6-month period.

Timeline

Start

2021-01-01

Primary completion

2023-12-31

Completion

2023-12-31

Publications

• He L, Mei H, Gu Y, Liu Z, Yang L, Li X, Wang X, Xu T. Combined impact of rituximab and target care on efficacy, quality of life, adverse reactions and recurrence rate in children with nephrotic syndrome: a randomized controlled trial. BMC Pediatr. 2025 Sep 24;25(1):691. doi: 10.1186/s12887-025-06070-0.

Drugs

Indications