drugset

drugset / Trial / NCT07049562

Study on the Mass Balance of [14C]HRS-8427 for Injection in Healthy Chinese Subjects

NCT07049562 ↗

Phase 1 Completed 6 enrolled Jiangsu HengRui Medicine Co., Ltd.

NaSingle-groupOpen-labelTreatment

Summary

To evaluate the absorption, metabolism and excretion after a single intravenous infusion of \[14C\]HRS-8427 in healthy Chinese subjects

Timeline

Start: 2025-05-21
Primary completion: 2025-06-18
Completion: 2025-06-18

Publications

Yin T, Qu B, Zhang Q, Xu S, Wu Y, Jiang H, Huang Y, Hu W. Pharmacokinetics, safety, and tolerability of HRS-8427, a novel anti-carbapenem-resistant cephalosporin, in healthy subjects. Antimicrob Agents Chemother. 2026 Apr;70(4):e0069425. doi: 10.1128/aac.00694-25. Epub 2026 Mar 3.

Drugs

Evaluation	Drug	Modality	Dose	Route
Subject	HRS-8427	Small molecule	—	Intravenous

Indications

No indication recorded.