drugset / Trial / NCT07057310

Aging Well: Targeting Obesity With GLP-1 Agonists to Enhance Physical and Vascular Health in Postmenopausal Women

NCT07057310

Phase 4 Enrolling by invitation 30 enrolled Mayo Clinic
RandomizedParallel-groupSingle-blindTreatment

Summary

In postmenopausal women, obesity increases the risk of physical function decline, premature aging, and vascular dysfunction. Semaglutide and tirzepatide are potent obesity medications. The goal is to determine the effect of weight loss induced by the new generation of GLP-1 receptor agonists on physical function, aging biomarkers, and vascular function in postmenopausal women with obesity.

Timeline

Start
2025-05-01
Primary completion
2026-12-31
Completion
2027-03-31

Drugs

EvaluationDrugModalityDoseRoute
Subject Semaglutide Peptide 2.4 mg
Subject Tirzepatide Peptide 15 mg

Indications