drugset / Trial / NCT07076550

A Phase 1-1b Study to Evaluate the Safety, Efficacy and Dosimetry of Study Drug A9-3408 in Subjects With Metastatic Melanoma

NCT07076550 ↗

Phase 1 Recruiting 50 enrolled Alpha-9 Oncology USA Inc.
Non-randomizedSequentialOpen-labelTreatment

Summary

The goal of this trial is to see if this investigational drug is safe for adult patients with melanoma that has spread to other parts of the body or cannot be removed by surgery. It will also see if this investigational drug can shrink melanoma tumors in the body. The main questions this study aims to answer are: * What are the side effects of this investigational drug? * What is the highest dose of this investigational drug that can be given safely? Participants will: * Take the investigational drug once every 6 weeks, for up to 6 times in total * Visit a doctor's office on a regular basis for checkups and tests

Timeline

Start
2025-11-19
Primary completion
2028-01
Completion
2028-01

Drugs

EvaluationDrugModalityDoseRoute
Subject [225Ac]Ac-A9-3408 Unknown — Intravenous