Efficacy of Striatin in Malnourished Children

Summary

This is a double-blind randomized-controlled clinical trial to identify the effect of Striatin (snakehead fish extract) supplementation in increasing body weight, improving acute inflammatory markers and microbiota profiles in children with severe acute malnutrition (SAM) treating with standard nutritional therapy. The main questions to answer are: Does Striatin supplementation effective in increasing body weight and improving acute inflammatory markers in SAM children? What are the adverse events of Striatin supplementation in SAM children? Researchers will compare Striatin supplementation and placebo (a look-alike substance that contains no drug) to identify the increase of body weight, improvement of acute inflammatory markers and microbiota profiles.

Timeline

Start

2025-05-20

Primary completion

2026-02-25

Completion

2026-04-16

Publications

• Background Sigh S, Roos N, Chamnan C, Laillou A, Prak S, Wieringa FT. Effectiveness of a Locally Produced, Fish-Based Food Product on Weight Gain among Cambodian Children in the Treatment of Acute Malnutrition: A Randomized Controlled Trial. Nutrients. 2018 Jul 16;10(7):909. doi: 10.3390/nu10070909.
• Background Puji Rahayu, Faustine Marcelline, Erna Sulistyaningrum, Maggy Thenawidjaja Suhartono, Raymond Rubianto Tjandrawinata, Potential effect of striatin (DLBS0333), a bioactive protein fraction isolated from Channa striata for wound treatment, Asian Pacific Journal of Tropical Biomedicine, Volume 6, Issue 12, 2016, Pages 1001-1007, ISSN 2221-1691, https://doi.org/10.1016/j.apjtb.2016.10.008. (https://www.sciencedirect.com/science/article/pii/S2221169115308534)

Drugs

Indications