Effect of Rose Odor Exposure on Ictal Apnea

Summary

This study will investigate the potential benefits of rose scent in reducing the risk of Sudden Unexpected Death in Epilepsy (SUDEP) in patients with epilepsy. Participants will engage in their routine inpatient observational EEG monitoring for 24 hours followed by an additional 24 hours of observational EEG monitoring with continuous exposure to rose scent, during which an essential oil diffusor with rose scent will be placed in their hospital room. During these 48 total hours of the study, participants will wear a respiratory monitoring belt across their upper chest to measure their breathing. Potential risks include distress or discomfort when smelling the rose scent used in the study, a physical reaction to the rose scent, and discomfort or feelings of restrictiveness when wearing the respiratory monitoring belt. The total time commitment of the study is 48 consecutive hours over the course of the participants' inpatient EMU stay, during which there will be no restrictions on daily activities during the standard inpatient EMU admission except that participants must wear their respiratory belt for a majority of this 2-day period.

Timeline

Start

2025-07-01

Primary completion

2027-05-08

Completion

2027-05-08

Publications

• Background Yilmaz Y, Turk BG, Ser MH, Sut NY, Sahin S, Yildiz EP, Bektas G, Teber ST, Tekeli H, Ozkara C. Seizure treatment with olfactory training: a preliminary trial. Neurol Sci. 2022 Dec;43(12):6901-6907. doi: 10.1007/s10072-022-06376-2. Epub 2022 Sep 6.
• Background Valentine PA, Fremit SL, Teskey GC. Sensory stimulation reduces seizure severity but not afterdischarge duration of partial seizures kindled in the hippocampus at threshold intensities. Neurosci Lett. 2005 Nov 4;388(1):33-8. doi: 10.1016/j.neulet.2005.06.028.
• Background Rhone AE, Kovach CK, Harmata GI, Sullivan AW, Tranel D, Ciliberto MA, Howard MA, Richerson GB, Steinschneider M, Wemmie JA, Dlouhy BJ. A human amygdala site that inhibits respiration and elicits apnea in pediatric epilepsy. JCI Insight. 2020 Mar 26;5(6):e134852. doi: 10.1172/jci.insight.134852.
• Background O'Neal TB, Shrestha S, Singh H, Osagie I, Ben-Okafor K, Cornett EM, Kaye AD. Sudden Unexpected Death in Epilepsy. Neurol Int. 2022 Jul 18;14(3):600-613. doi: 10.3390/neurolint14030048.
• Background Nobis W, Huffman R, Mitchell A, Hannalla M. 512 Odorant exposure decreases mortality in a Dravet Syndrome mouse model. J Clin Transl Sci. 2023;7(Suppl 1):145. Published 2023 Apr 24. doi:10.1017/cts.2023.511
• Background Nobis WP, Gonzalez Otarula KA, Templer JW, Gerard EE, VanHaerents S, Lane G, Zhou G, Rosenow JM, Zelano C, Schuele S. The effect of seizure spread to the amygdala on respiration and onset of ictal central apnea. J Neurosurg. 2019 Apr 5;132(5):1313-1323. doi: 10.3171/2019.1.JNS183157. Print 2020 May 1.
• Background Nguyen MQ, Ryba NJ. A smell that causes seizure. PLoS One. 2012;7(7):e41899. doi: 10.1371/journal.pone.0041899. Epub 2012 Jul 27.
• Background Motoki A, Akamatsu N, Fumuro T, Miyoshi A, Tanaka H, Hagiwara K, Ohara S, Kamada T, Shigeto H, Murai H. Characteristics of olfactory dysfunction in patients with temporal lobe epilepsy. Epilepsy Behav. 2021 Dec;125:108402. doi: 10.1016/j.yebeh.2021.108402. Epub 2021 Nov 12.
• Background Lunardi MS, Lin K, Mameniskiene R, Beniczky S, Bogacz A, Braga P, Guaranha MSB, Yacubian EMT, Samaitiene R, Baykan B, Hummel T, Wolf P. Olfactory stimulation induces delayed responses in epilepsy. Epilepsy Behav. 2016 Aug;61:90-96. doi: 10.1016/j.yebeh.2016.05.022. Epub 2016 Jun 23.
• Background Li Z, Chen L, Xu C, Chen Z, Wang Y. Non-invasive sensory neuromodulation in epilepsy: Updates and future perspectives. Neurobiol Dis. 2023 Apr;179:106049. doi: 10.1016/j.nbd.2023.106049. Epub 2023 Feb 20.

Drugs

Indications