drugset / Trial / NCT07120984
A Study to Evaluate the Safety and Efficacy of L19TNF With Alkylating Chemotherapy for Patients With Recurrent IDH-mutant Astrocytoma or Oligodendroglioma
Non-randomizedParallel-groupOpen-labelTreatment
Summary
The purpose of this study is to explore the safety and efficacy of the antibody-cytokine fusion protein L19TNF alone or in combination with alkylating chemotherapy in patients with recurrent IDH mutant glioma.
Timeline
- Start
- 2026-01-30
- Primary completion
- 2029-01-30
- Completion
- 2029-01-30
Drugs
| Evaluation | Drug | Modality | Dose | Route |
|---|---|---|---|---|
| Subject | Lomustine | Small molecule | — | — |
| Subject | Onfekafusp alfa | Protein / enzyme biologic | 13 ug/kg | — |
| Subject | Temozolomide | Small molecule | — | — |