drugset / Trial / NCT07128355

Botensilimab, Balstilimab, and SBRT in Colorectal Cancer

NCT07128355

Phase 0 Recruiting 15 enrolled Massachusetts General Hospital Agenus Inc. · collab
NaSingle-groupOpen-labelTreatment

Summary

This is a single-arm pilot feasibility study evaluating the combination of Botensilimab and Balstilimab with Radiation Therapy (RT) in Non-Microsatellite Instability High (MSI-H) or Proficient Mismatch Repair (pMMR) chemorefractory colorectal cancer (CRC) with liver metastasis.

Timeline

Start
2026-05-12
Primary completion
2027-01-01
Completion
2027-09

Drugs

EvaluationDrugModalityDoseRoute
Subject Balstilimab Monoclonal antibody Intravenous
Subject Botensilimab Monoclonal antibody Intravenous