drugset / Trial / NCT07133750

PM8002 (BNT327) in Combination With Chemotherapy in Patients With Metastatic Colorectal Cancer

NCT07133750

Phase 2 Not yet recruiting 40 enrolled BioNTech SE
RandomizedParallel-groupOpen-labelTreatment

Summary

PM8002 (BNT327) is a bispecific antibody targeting PD-L1 and VEGF. This is a phase II trial to evaluate the efficacy and safety of PM8002 in combination with chemotherapy in first line MSS or MSI-L/pMMR metastatic colorectal cancer.

Timeline

Start
2025-08
Primary completion
2026-08
Completion
2029-08

Drugs

EvaluationDrugModalityDoseRoute
Subject Pumitamig Protein / enzyme biologic Intravenous

Indications