drugset / Trial / NCT07136428

Asciminib in HER2+ Breast Cancer Brain Metastases

NCT07136428

Phase 1/2 Not yet recruiting 42 enrolled Duke University Novartis · collab
NaSingle-groupOpen-labelTreatment

Summary

The purpose of this study is to evaluate the intracranial response rate of a combination of asciminib/trastuzumab for the treatment of patients with metastatic HER2+ breast cancer with brain metastases.

Timeline

Start
2026-07
Primary completion
2030-11-01
Completion
2032-11-01

Drugs

EvaluationDrugModalityDoseRoute
Subject Asciminib Unknown 40 mg Oral
Subject Asciminib Unknown 80 mg Oral
Subject Asciminib Unknown 200 mg Oral
Subject Trastuzumab Monoclonal antibody 6 mg/kg Intravenous