Optimizing Linezolid Dosing in Patients With Advanced Renal Impairment: a Therapeutic Drug Monitoring-based Evaluation

Summary

The goal of this clinical trial is to adjust the Linezolid dose according to its blood level in adults with kidney diseases. It will also learn about the safety of linezolid. The main questions it aims to answer are: * How often does linezolid require level monitoring? * How often does linezolid require dose adjustment? * What medical benefits do participants have when linezolid level monitoring is applied? Researchers will compare two dose reduction regimens when they have evidence of overexposure to determine which regimen is more effective in preventing thrombocytopenia (Platelet drop). Participants will: * Withdrew linezolid level every 2 to 4 days of the antibiotic course. * Visit the clinic twice for checkups and tests.

Timeline

Start

2025-10-15

Primary completion

2025-12-15

Completion

2026-05-15

Drugs

Indications