Effect of Systemic Retinoic Acid Use on Micro Ribonucleic Acid (mRNA) Expression

Summary

Ribonucleic acids (RNA) are molecules that transfer genetic information from the nucleus to the cytoplasm for protein translation. A subgroup of non-coding or non-messenger RNAs, known as microRNAs (miRNAs), regulates the expression of complementary mRNAs without coding for proteins. In this study, the investigators aimed to evaluate the effect of systemically administered oral isotretinoin on gingival health in terms of microRNA (miRNA), a molecule of interest in periodontal research, before, during, and after treatment.

Timeline

Start

2025-09-01

Primary completion

2025-12-31

Completion

2026-02-01

Drugs

Indications